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<h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Mx1</span></h1>
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<div id="mw-content-text" class="mw-body-content mw-content-ltr" lang="de" dir="ltr"><div class="mw-content-ltr mw-parser-output" lang="de" dir="ltr"><table class="wikitable hintergrundfarbe-basis infobox float-right" id="Vorlage_Infobox_Protein_Mx1" style="font-size:90%; margin-top:0; width:350px;" summary="Infobox Protein">
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<th colspan="3" style="background:#90EE90; color:#202122;">Mx1
</th></tr>
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<td>Andere Namen
</td>
<td colspan="2">
<ul><li>IFI-78K</li>
<li>IFI78</li>
<li>MX</li>
<li>MxA</li></ul>
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<td colspan="3" class="hintergrundfarbe1" style="font-size:smaller;">
<p>Vorhandene Strukturdaten: <span class=""><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3LJB">3LJB</a></span>, <span class=""><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3SZR">3SZR</a></span>, <span class=""><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3ZYS">3ZYS</a></span>, <span class=""><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4P4S">4P4S</a></span>, <span class=""><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4P4T">4P4T</a></span>, <span class=""><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4P4U">4P4U</a></span>
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<th colspan="3" style="background:#90EE90; color:#202122;;">Eigenschaften des menschlichen Proteins
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<td><a href="Molare_Masse" title="Molare Masse">Masse</a>/Länge <a href="Prim%C3%A4rstruktur" title="Primärstruktur">Primärstruktur</a>
</td>
<td colspan="2" style="text-align:center;">75.520 <a href="Atomare_Masseneinheit" title="Atomare Masseneinheit">Dalton</a> / 662 <a href="Aminos%C3%A4ure" class="mw-redirect" title="Aminosäure">Aminosäuren</a>
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<td><a href="Isoform" title="Isoform">Isoformen</a>
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<td colspan="2" style="text-align:center;">2
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<th colspan="3" style="background:#90EE90; color:#202122;">Bezeichner
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<td><a href="Human_Genome_Organisation" title="Human Genome Organisation">Gen-Namen</a>
</td>
<td colspan="2" class="" style="text-align:center;"><i><a rel="nofollow" class="external text" href="https://www.genenames.org/tools/search/#!/all?query=7532">MX1</a></i>, IFI78, MxA, MX
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<tr>
<td>Externe IDs
</td>
<td colspan="2" class="">
<ul><li><a href="GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=MX1">MX1</a></li>
<li><a href="Online_Mendelian_Inheritance_in_Man" title="Online Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/omim/147150">147150</a></li>
<li><a href="UniProt" title="UniProt">UniProt</a> <a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprotkb/P20591">P20591</a></li>
<li><a href="Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="https://www.informatics.jax.org/marker/MGI:97244">97244</a></li></ul>
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<th colspan="3" style="background:#90EE90; color:#202122;">Vorkommen
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<td style="background:#C3FDB8; color:#202122;">Homologie-Familie
</td>
<td colspan="2" style="text-align:center;"><a rel="nofollow" class="external text" href="http://hogenom.univ-lyon1.fr/query_sequence?seq=P20591">Hovergen</a>
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<tr>
<td colspan="3" style="background:#90EE90; color:#202122; text-align:center;"><a href="Homologie_(Genetik)#Homologie_zwischen_verdoppelten_oder_fremden_Genen" title="Homologie (Genetik)">Orthologe</a>
</td></tr>
<tr>
<td style="background:#C3FDB8; color:#202122;">
</td>
<td style="background:#C3FDB8; color:#202122; text-align:center;">Mensch
</td>
<td style="background:#C3FDB8; color:#202122; text-align:center;">Hausmaus
</td></tr>
<tr>
<td style="background:#C3FDB8; color:#202122;"><a href="Entrez_Gene" title="Entrez Gene">Entrez</a>
</td>
<td><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=4599&rn=1">4599</a></span>
</td>
<td><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=17858&rn=1">17858</a></span>
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<td style="background:#C3FDB8; color:#202122;"><a href="Ensembl" title="Ensembl">Ensembl</a>
</td>
<td><span class=""><small><small><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000157601;db=core">ENSG00000157601</a></small></small></span>
</td>
<td><span class=""><small><small><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000023341;db=core">ENSMUSG00000023341</a></small></small></span>
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<tr>
<td style="background:#C3FDB8; color:#202122;"><a href="UniProt" title="UniProt">UniProt</a>
</td>
<td><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprotkb/P20591">P20591</a>
</td>
<td><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprotkb/Q61924">Q61924</a>
</td></tr>
<tr>
<td style="background:#C3FDB8; color:#202122;"><a href="National_Center_for_Biotechnology_Information" title="National Center for Biotechnology Information">Refseq</a> (mRNA)
</td>
<td><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001144925">NM_001144925</a>
</td>
<td><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_013606">NM_013606</a>
</td></tr>
<tr>
<td style="background:#C3FDB8; color:#202122;"><a href="National_Center_for_Biotechnology_Information" title="National Center for Biotechnology Information">Refseq</a> (Protein)
</td>
<td><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001138397">NP_001138397</a>
</td>
<td><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_038634">NP_038634</a>
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<tr>
<td style="background:#C3FDB8; color:#202122;"><a href="Genlocus" title="Genlocus">Genlocus</a>
</td>
<td><span class=""> <a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human?db=hg38&position=chr21:41420304-41459214">Chr 21: 41.42 – 41.46 Mb</a> </span>
</td>
<td><span class=""> <a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?db=mm9&position=chr16:97690999-97715817">Chr 16: 97.69 – 97.72 Mb</a> </span>
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<td style="background:#C3FDB8; color:#202122;"><a href="PubMed" title="PubMed">PubMed</a>-Suche
</td>
<td><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=4599">4599</a></span>
</td>
<td><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=17858">17858</a></span>
<p><span class="editoronly" style="display:none;"></span>
</p>
</td></tr></tbody></table><p><span class="editoronly" style="display:none;"></span>
</p><p><b>Mx1</b> (<span style="font-style:normal;font-weight:normal"><a href="Englische_Sprache" title="Englische Sprache">englisch</a></span> <span lang="en-Latn" style="font-style:italic"><i>Interferon-induced GTP-binding protein Mx1</i></span> ‚Interferon-induziertes GTP-bindendes Protein Mx1‘, synonym <i>MxA</i>) ist eine <a href="GTPase" class="mw-redirect" title="GTPase">GTPase</a> und ein <a href="Resistenzfaktor" class="mw-redirect" title="Resistenzfaktor">Resistenzfaktor</a> gegen <a href="RNA-Viren" class="mw-redirect" title="RNA-Viren">RNA-Viren</a>, insbesondere gegen solche mit einem <a href="Genom" title="Genom">Genom</a> negativer <a href="Polarit%C3%A4t_(Virologie)" title="Polarität (Virologie)">Polarität</a> wie das <a href="Influenzavirus_A" class="mw-redirect" title="Influenzavirus A">Influenzavirus A</a>.
</p>
<div class="mw-heading mw-heading2"><h2 id="Eigenschaften">Eigenschaften</h2></div>
<p>Die <a href="Genexpression" title="Genexpression">Genexpression</a> des Mx1 wird durch <a href="Interferon" class="mw-redirect" title="Interferon">Interferone</a> des Typs I und III induziert,<sup id="cite_ref-PMID_24296571_1-0" class="reference"><a href="#cite_note-PMID_24296571-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> z. B. während einer Infektion mit <a href="Influenzaviren" title="Influenzaviren">Influenzaviren</a>.<sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> Das Gen des Mx1 kommt in allen Wirbeltieren in ein bis drei Kopien vor,<sup id="cite_ref-PMID_24296571_1-1" class="reference"><a href="#cite_note-PMID_24296571-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> mit Ausnahme von <a href="Zahnwale" title="Zahnwale">Zahnwalen</a>.<sup id="cite_ref-DOI10.1073/pnas.1501844112_3-0" class="reference"><a href="#cite_note-DOI10.1073/pnas.1501844112-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> Vermutlich bindet Mx1 an das <a href="Ribonukleoprotein" title="Ribonukleoprotein">Ribonukleoprotein</a>.<sup id="cite_ref-PMID_24296571_1-2" class="reference"><a href="#cite_note-PMID_24296571-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> Mx1 bildet ringförmige <a href="Oligomer" title="Oligomer">Oligomere</a> um <a href="Liposom" title="Liposom">Liposomen</a>.<sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup>
</p>
<div class="mw-heading mw-heading2"><h2 id="Einzelnachweise">Einzelnachweise</h2></div>
<ol class="references">
<li id="cite_note-PMID_24296571-1"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-PMID_24296571_1-0">a</a></sup> <sup><a href="#cite_ref-PMID_24296571_1-1">b</a></sup> <sup><a href="#cite_ref-PMID_24296571_1-2">c</a></sup></span> <span class="reference-text">J. Verhelst, P. Hulpiau, X. Saelens: <i>Mx proteins: antiviral gatekeepers that restrain the uninvited.</i> In: <i>Microbiology and molecular biology reviews : MMBR.</i> Band 77, Nummer 4, Dezember 2013, <span class="-print"><a href="Internationale_Standardnummer_f%C3%BCr_fortlaufende_Sammelwerke" title="Internationale Standardnummer für fortlaufende Sammelwerke">ISSN</a> <span style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://zdb-katalog.de/list.xhtml?t=iss%3D%221098-5557%22&key=cql">1098-5557</a></span></span>, S. 551–566, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1128/MMBR.00024-13">10.1128/MMBR.00024-13</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/24296571?dopt=Abstract">PMID 24296571</a>, <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973384/">PMC 3973384</a> (freier Volltext).</span>
</li>
<li id="cite_note-2"><span class="mw-cite-backlink"><a href="#cite_ref-2">↑</a></span> <span class="reference-text">O. Haller, P. Staeheli, M. Schwemmle, G. Kochs: <i>Mx GTPases: dynamin-like antiviral machines of innate immunity.</i> In: <i>Trends in microbiology.</i> Band 23, Nummer 3, März 2015, <span class="-print"><a href="Internationale_Standardnummer_f%C3%BCr_fortlaufende_Sammelwerke" title="Internationale Standardnummer für fortlaufende Sammelwerke">ISSN</a> <span style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://zdb-katalog.de/list.xhtml?t=iss%3D%221878-4380%22&key=cql">1878-4380</a></span></span>, S. 154–163, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1016/j.tim.2014.12.003">10.1016/j.tim.2014.12.003</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/25572883?dopt=Abstract">PMID 25572883</a>.</span>
</li>
<li id="cite_note-DOI10.1073/pnas.1501844112-3"><span class="mw-cite-backlink"><a href="#cite_ref-DOI10.1073/pnas.1501844112_3-0">↑</a></span> <span class="reference-text">Benjamin A. Braun, Amir Marcovitz, J. Gray Camp, Robin Jia, Gill Bejerano: <i>Mx1 and Mx2 key antiviral proteins are surprisingly lost in toothed whales.</i> In: <i>Proceedings of the National Academy of Sciences.</i>, S. 201501844, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1073/pnas.1501844112">10.1073/pnas.1501844112</a></span>.</span>
</li>
<li id="cite_note-4"><span class="mw-cite-backlink"><a href="#cite_ref-4">↑</a></span> <span class="reference-text">O. Haller, G. Kochs: <i>Human MxA protein: an interferon-induced dynamin-like GTPase with broad antiviral activity.</i> In: <i>Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.</i> Band 31, Nummer 1, Januar 2011, <span class="-print"><a href="Internationale_Standardnummer_f%C3%BCr_fortlaufende_Sammelwerke" title="Internationale Standardnummer für fortlaufende Sammelwerke">ISSN</a> <span style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://zdb-katalog.de/list.xhtml?t=iss%3D%221557-7465%22&key=cql">1557-7465</a></span></span>, S. 79–87, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1089/jir.2010.0076">10.1089/jir.2010.0076</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/21166595?dopt=Abstract">PMID 21166595</a>.</span>
</li>
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